MIDGE^®-Th1 vector system

Immense importance for DNA vaccination

As with all vectors in the MIDGE^® vector system from MOLOGEN AG, the MIDGE^®-Th1 vector also carries only the minimal amount of genetic information required to exert its effect and exhibits the small size characteristic of the MIDGE^® vector system.

The Th1 type of the Smart MIDGE^® vectors carries a signaling module that is permanently bonded to a defined point in the single-stranded hairpin structure on one side of the vector. The MIDGE^®-Th1 vector possesses greater efficacy than other vectors. In other words, the expression of the genetic information stored on the vector is stronger. The MIDGE^®-Th1 vector also induces a cellular immune response of the type known as Th1. It is therefore particularly suitable for DNA vaccination against infectious diseases that require a cellular immune response for protection against the disease, such as viral illnesses. The parasitic disease Leishmaniasis also requires a cellular immune response for the successful fight against the pathogen. 

MOLOGEN AG is using the MIDGE^®-Th1 technology in the research and development of vaccines against Leishmaniasis and hepatitis B, for example.